#38 - Esperance Therapeutics: Tackling Fish Odor Syndrome (TMAU) with Synthetic Biology

In this episode of the InNOLEvation® Mindset Podcast, hosted by Mark McNees and powered by the Jim Moran College of Entrepreneurship, we explore the groundbreaking work of Zachary Asarnow and Ava Polly from the FSU iGEM team, Esperance. Discover how this team is developing a cell-based therapeutic to address Fish Odor Syndrome (TMAU), a rare genetic disorder. Learn about the impact of TMAU on patients' lives, the team's innovative approach using FDA-approved E. coli bacteria, and their journey through the iGEM international synthetic biology competition. The episode also highlights the support from their advisors, the hurdles they face, and their ambitious goals for the future.

 

00:00 Introduction and Guest Welcome

00:30 Understanding iGEM and Esperance

01:09 Exploring Fish Odor Syndrome (TMAU)

02:50 Personal Experience with TMAU

04:16 Challenges Faced by TMAU Patients

05:07 Therapeutic Treatment Development

07:02 iGEM Team Structure and Roles

11:46 InNOLEvation® Challenge Experience

14:42 Student Journeys and Future Goals

17:53 Preparing for the iGEM Competition

21:07 Overcoming Obstacles and Defining Success

24:05 Support and Acknowledgements

27:41 Conclusion and Farewell